Before coming to the Fuka Academy, all Mai Tokiha wanted was to live an ordinary high school life, but that's the last thing she's going to get. It turns out that Mai is a HiME, one of twelve girls with super-natural powers that are gathered at this school to fight the Orphans, demons that dwell around the school. A secret organization has other plans for the HiME than just demon-busting and Mai and the other HiME will have to risk something precious to protect the ones they love.